METHYLATION HEALTHCARE
for Physical & Mental Health
[ This is a legacy site maintained by Methyl Health for limited reference. To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here, and see www.methyl.health for more. Note: data presented via linked-to sources may or not be current as originally provided for due to external providers' changes at any time. Methyl Health is also tracking for such changes and future reporting. Thank you for your understanding. ]
As Total-health Advocates
We acknowledge the complexity of task posed for genomics care providers over personalized medicine, and for clinical-pediatric recommendations/abstention.Current foci here includes preservation of infant-transferase systems and maintenance for compromised, post-infantile systems.OTHER: For maternal-methyl supplementation, the role of pteroylglutamic acid and other synthetics require further study as we interpret findings from adverse events for toxic levels (see Unmetabolized Folic Acid - U.S. National Library) of "folic" acid (non-equating with folate: do not use interchangeably) in maternal bodies detected at the time of childbearing. (Layman's Terms: At minimum, persons concerned regarding cancer etc. and pregnant women should limit or eliminate pteroylglutamic acid. For other-healthy persons, consider the disadvantage of converting synthetics ingested compared to natural food.)
Suggestions [data] presently include injury to transferase systems incurred in some circumstances through introduction of substrates via routine administrations. (Layman's Terms: [redacted per legacy content])
MAYO CLINIC, Abstract: "Background: The objective was to assess the association between increasing autism incidence rates and the increasing dose of folic acid in prescription prenatal and pediatric vitamins. Methods: We used published autism incidence rates from the Rochester Epidemiological Project in Rochester, MN, for 1976-1997. Additionally, we used the percent of prescription prenatal vitamins containing [...] Conclusions: If it is true that too little folic acid results in nervous tissue damage, as is accepted by the scientific community in regard to neural tube defects (NTDs), then it seems plausible that too much folic acid may result in nervous tissue damage associated with autism. Although the correlations described here do not provide proof of causation, these data provide an impetus for further study. Children who develop autism may be receiving a massive dose of folic acid in utero, as well as, after birth. It would be of interest to carry out a case-control study using medical record data to document folic acid intake for pregnant women whose offspring were later diagnosed with autism and controls." [See Methyl Health Case Studies further below.]U.S. National Library of Medicine: National Center for Biotechnology Information, Abstract: Inappropriate diet may contribute to one third of cancer deaths. Folates, a group of water-soluble B vitamins present in high concentrations in green, leafy vegetables, maintain DNA stability through their ability to donate one-carbon units for cellular metabolism. Folate deficiency has been implicated in the development of several cancers, including cancer of the colorectum, breast, ovary, pancreas, brain, lung and cervix. Generally, data from the majority of human studies suggest that people who habitually consume the highest level of folate, or with the highest blood folate concentrations, have a significantly reduced risk of developing colon polyps or cancer. However, an entirely protective role for folate against carcinogenesis has been questioned, and recent data indicate that an excessive intake of synthetic folic acid [pteroylglutamic acid] (from high-dose supplements or fortified foods) may increase human cancers by accelerating growth of precancerous lesions. Nonetheless, on balance, evidence from the majority of human studies indicates that dietary folate is genoprotective against colon cancer. Suboptimal folate status in humans is widespread. Folate maintains genomic stability by regulating DNA biosynthesis, repair and methylation. Folate deficiency induces and accelerates carcinogenesis by perturbing each of these processes. This review presents recent evidence describing how these mechanisms act, and interact, to modify colon cancer risk."
To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here.
Advisement
METHYL HEALTH, 2/3/21: [Redacted per legacy content]
METHYL HEALTH, 10/30/19: Centers for Disease Control and Prevention does not readily concur with some significant findings presented by the U.S. National Center for Biotechnology/National Library of Medicine/National Insitutes of Health. Methylation Healthcare bridges this and in instances corrects on behalf of many persons who have experienced adverse effects from unduly burdened methyl health. You are invited to submit articles towards the methyl-friendly initiative by [ ... To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here].
METHYL HEALTH, 1/7/19: Compromise to transferase systems implicates not limited to metabolism impact for prescriptive treatments. For provider patient-concerns, please consult indices over genomics/related you may be unfamiliar with - levering personal research for executed due-diligence advancing personalized-care decisions for those you serve.
METHYL HEALTH SUCCOR
METHYL HEALTH, 2/3/21: [Redacted per legacy content]
METHYL HEALTH, 10/30/19: Centers for Disease Control and Prevention does not readily concur with some significant findings presented by the U.S. National Center for Biotechnology/National Library of Medicine/National Insitutes of Health. Methylation Healthcare bridges this and in instances corrects on behalf of many persons who have experienced adverse effects from unduly burdened methyl health. You are invited to submit articles towards the methyl-friendly initiative by [ ... To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here].
METHYL HEALTH, 1/7/19: Compromise to transferase systems implicates not limited to metabolism impact for prescriptive treatments. For provider patient-concerns, please consult indices over genomics/related you may be unfamiliar with - levering personal research for executed due-diligence advancing personalized-care decisions for those you serve.
Presently, we see abstention from recommendation ("no recommendation at this time") from Children's Hospital Minnesota, Genomics on the matter of managed concerns over maintenance of in-tact transferase and the route-administrations dilemma. [edited 10/31/19]
METHYL / VACCINOMICS CASE STUDIES FOR ADVERSOMICS
Note: There is no overlap for case-groups/persons below as distinct, seperate.)
Recommendation: Check back for extant data/material findings to be posted.
Final Recommendation:
For Public and Care Providers: If you need help, please speak with providers knowleadgable in genomics, personalized medicine or similar. Through any events for which you do not know how to proceed, please choose caution and reach out. Child(ren) or persons in your care should receive treatments non-injurious to their long-term health. ### To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here.
METHYL / VACCINOMICS CASE STUDIES FOR ADVERSOMICS
Note: There is no overlap for case-groups/persons below as distinct, seperate.)
ADVERSOMICS, Case 1: Non-vaccinated child, quaternary in birth-order, scores no autism in contrast to vaccinated, bio-familial siblings primary through tertiary.Recommendation (here, non-PharmD)—At this time: If you are contemplating inoculates or vaccines, first understand through familial search, testing and analyses the historic conditions discoverable regarding transferase-systemic scores et al. and posing risk.
ADVERSOMICS, Case 2: Non-vaccinated child, quaternary in birth-order, scores favored transferase in contrast to vaccinated, bio-familial siblings primary through tertiary.
Recommendation: Check back for extant data/material findings to be posted.
Final Recommendation:
For Public and Care Providers: If you need help, please speak with providers knowleadgable in genomics, personalized medicine or similar. Through any events for which you do not know how to proceed, please choose caution and reach out. Child(ren) or persons in your care should receive treatments non-injurious to their long-term health. ### To discuss your clinical research or associated findings, please reach The Methyl Group via Methyl Health at form here.
Resources
Links
CDC Transferase Query: https://www.cdc.govDefinitive: http://www.methyl.health
Scholarly: U.S. National Library of Medicine
WHO: http://www.who.int